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Various research papers are indicating a clear association between inflammatory arthritis and latent gut bacterial infections. though the exact trigger in most autoimmune diseases is unknown, however underlying latent infectious pathology has been suggested to be playing an important role in the development of autoimmunity. the current rapid rise in the number of autoimmune diseases cannot be explained only on the basis of genetic association. through the involvement of exogenous environmental factors in the form of microbial infections [1]. In this review, we are discussing the role of microbes in some immune-mediated rheumatologic disorders, such as rheumatic fever, Lyme disease, reactive arthritis (ReA), RA, ankylosing spondylitis (AS), and Crohn’s disease (CD).

Various research papers are indicating a clear association between inflammatory arthritis and latent gut bacterial infections. though the exact trigger in most autoimmune diseases is unknown, however underlying latent infectious pathology has been suggested to be playing an important role in the development of autoimmunity. the current rapid rise in the number of autoimmune diseases cannot be explained only on the basis of genetic association. through the involvement of exogenous environmental factors in the form of microbial infections [1]. In this review, we are discussing the role of microbes in some immune-mediated rheumatologic disorders, such as rheumatic fever, Lyme disease, reactive arthritis (ReA), RA, ankylosing spondylitis (AS), and Crohn’s disease (CD).

Ankylosing spondylitis (AS) is a chronic inflammatory spinal and large-joint arthritic condition. Based on various studies carried out by independent research groups suggests that Klebsiella pneumoniae is the main microbial agent being implicated as a trigger in AS.

our comprehensive stool testing is able to identify the gut dysbiosis and presence of these gut bacterias which cause molecular mimicry Klebsiella antibodies could be used in the detection of Ankylosing Spondylitis patients during the early stages of the disease.

Once diagnosed, functional medicine protocols directed towards curbing these infections help in reducing the inflammatory reactions.

HLA-B27 is a genetic marker. If found positive it denotes inflammatory arthritis of the spine and joints (not osteoarthritis),  The spectrum includes diseases such as ankylosing spondylitis (AS), psoriatic arthritis, and Reiter’s syndrome (also called reactive arthritis).

HLA-B27 is present in about 90% of people with AS.

Dr Kalpana Shekhawat M.D.

Functional medicine specialist

Chairperson FMMA

Founder Director of Freedom Age